Brennan A. Murphy, Ph.D.

202-970-3180
bmurphy@fenwick.com
Patent Agent
Intellectual Property

Brennan A.
Murphy, Ph.D.

Brennan A.
Murphy, Ph.D.

Brennan A.
Murphy, Ph.D.

Patent Agent
Intellectual Property

Brennan is a patent agent in Fenwick’s intellectual property and life sciences groups. He applies his scientific and legal training toward drafting, prosecuting, and securing patent rights for clients in the chemical, biotechnological, and pharmaceutical arts. Brennan has experience in process chemistry, medicinal chemistry, drug discovery, polymers, catalysis, and pharmaceutical formulations. Brennan also assists with preparation of legal opinions, e.g., patentability, freedom-to-operate, and validity opinions, and conducts due diligences of patent estates.

Brennan’s graduate and post-graduate scientific work focused on the design, synthesis, and biological evaluation of antibiotics, antivirals, antineoplastics, opioids, neurotoxins, dyes, and other tools in the fields of synthetic chemistry and chemical biology.

  • Patent No. 9,475,823 B2: Methods for the Preparation of Hydromorphone

  • Patent No. 9,475,823 B2: Methods for the Preparation of Hydromorphone

  • Chemically Tagging Cargo for Specific Packaging inside and on the Surface of Virus-like Particles Tariq Hussain, Zhongchao Zhao, Brennan Murphy, Zachary E. Taylor, Jessica A. Gudorf, Shelby Klein, Lauren F. Barnes, Michael VanNieuwenhze, Martin F. Jarrold, Adam Zlotnick ACS Nano 2024, 18, 32, 21024-21037 DOI: 10.1021/acsnano.4c02056
  • Neutral sphingomyelinase 2 inhibitors based on the pyrazolo[1,5-a]prymidin-3-amine scaffold Katerina Novotna, Ajit G. Thomas, Ondrej Stepanek, Brennan Murphy, Niyada Hin, Jan Skacel, Louis Mueller, Lukas Tenora, Arindom Pal, Jesse Alt, Ying Wu, James Paule, Rana Rais, Barbara S. Slusher, Takashi Tsukamoto European Journal of Organic Chemistry 2023 DOI: 10.1016/j.ejmech.2023.115674.
  • A Far-Red Rotor Fluorogenic Trehalose Probe for Live Mycobacteria Detection and Drug-Susceptibility Testing Nicholas Banahene, Dana M Gepford, Kyle J. Biegas, Daniel H. Swanson, Yen‐Pang Hsu, Brennan A Murphy, Zachary E. Taylor, Irene Lepori, M. Sloan Siegrist, Andrés Obregón‐Henao, Michael S. Van Nieuwenhze, Benjamin M. Swarts Angewandte Chemie 2023 DOI: 10.1002/anie.202213563.
  • High-throughput activity assay for screening inhibitors of the SARS-CoV-2 Mac1 macrodomain Morgan Dasovich, Junlin Zhuo, Jack A. Goodman, Ajit Thomas, Robert Lyle McPherson, Aravinth Kumar Jayabalan, Veronica F. Busa, Shang-Jung Cheng, Brennan A. Murphy, Karli R Redinger, Yousef M. O. Alhammad, Anthony R Fehr, Takashi Tsukamoto, Barbara S. Slusher, Jürgen Bosch, Huijun Wei, Anthony KL Leung ACS Chemical Biology 2021. DOI: 10.1021/acschembio.1c00721.
  • The Pneumococcal Iron Uptake Protein a (PiuA) Specifically Recognizes Tetradentate FeIII bis- and Mono-Catechol Complexes Yifan Zhang, Katherine A. Edmonds, Daniel J. Raines, Brennan A. Murphy, Hongwei Wu, Chuchu Guo, Elizabeth M. Nolan, Michael S. VanNieuwenhze, Anne-K. Duhme-Klair, and David P. Giedroc Journal of Molecular Biology 2020. DOI: 10.1016/j.jmb.2020.08.005.
  • Scalable Synthesis of Orthogonally Protected β-Methyllanthionines by Indium(III)-Mediated Ring Opening of Aziridines Ziran Li, Zachary Gentry, Brennan Murphy, and Michael S. VanNieuwenhze Organic Letters 2019, 21, 2200-2203. DOI: 10.1021/acs.orglett.9b00125.
  • Fluorogenic D-amino acids enable real-time monitoring of peptidoglycan biosynthesis and high-throughput transpeptidation assays Yen-Pang Hsu, Edward Hall, Garrett Booher, Brennan Murphy, Atanas D. Radkov, Jacob Yablonowski, Caitlyn Mulcahey, Laura Alvarez, Felipe Cava, Yves V. Brun, Erkin Kuru, and Michael S. VanNieuwenhze Nature Chemistry 2019, 11, 335-341. DOI: 10.1038/s41557-019-0217-x.
  • Chemoenzymatic Synthesis of Advanced Intermediates for Formal Total Syntheses of Tetrodotoxin Daler Baidilov, Lukas Rycek, John F. Trant, Jordan Froese, Brennan Murphy, and Tomáš Hudlický Angewandte Chemie International Edition 2018, 57, 10994-10998. DOI: 10.1002/anie.201804602.
  • Full color palette of fluorescent D-amino acids for in situ labeling of bacterial cell walls Yen-Pang Hsu, Jonathan Rittichier, Erkin Kuru, Jacob Yablonowski, Erick Pasciak, Srinivas Tekkam, Edward Hall, Brennan Murphy, Timothy K. Lee, Ethan C. Garner, Kerwyn Casey Huang, Yves V. Brun, and Michael S. VanNieuwenhze Chemical Science 2017, 8, 6313-6321. DOI: 10.1039/C7SC01800B.
  • A Formal Approach to Xylosmin and Flacourtosides E and F: Chemoenzymatic Total Synthesis of the Hydroxylated Cyclohexenone Carboxylic Acid Moiety of Xylosmin Mukund Ghavre, Jordan Froese, Brennan Murphy, Razvan Simionescu, and Tomáš Hudlický Organic Letters 2017, 19, 1156-1159. DOI: 10.1021/acs.orglett.7b00194.
  • Rosmarinic Acid, a Rosemary Extract Polyphenol, Increases Skeletal Muscle Cell Glucose Uptake and Activates AMPK Filip Vlavcheski, Madina Naimi, Brennan Murphy, Tomáš Hudlický, and Evangelia Tsiani Molecules 2017, 22, 1669. 10.3390/molecules22101669.
  • Carnosic acid as a component of rosemary extract stimulates skeletal muscle cell glucose uptake via AMPK activation Madina Naimi, Filip Vlavcheski, Brennan Murphy, Tomáš Hudlický, and Evangelia Tsiani Clinical and Experimental Pharmacology and Physiology 2017, 44, 94–102. DOI: 10.1111/1440-1681.12674.
  • Conversion of Thebaine to Oripavine and Other Useful Intermediates for the Semi-synthesis of Opiate-Derived Agents. Synthesis of Hydromorphone Brennan Murphy, Ivan Šnajdr, Aleš Machara, Mary Ann A. Endoma-Arias, Theocharis C. Stamatatos, D. Phillip Cox, and Tomáš Hudlický Advanced Synthesis & Catalysis 2014, 356, 2679-2687. DOI: 10.1002/adsc.201400445.

  • Chemically Tagging Cargo for Specific Packaging inside and on the Surface of Virus-like Particles Tariq Hussain, Zhongchao Zhao, Brennan Murphy, Zachary E. Taylor, Jessica A. Gudorf, Shelby Klein, Lauren F. Barnes, Michael VanNieuwenhze, Martin F. Jarrold, Adam Zlotnick ACS Nano 2024, 18, 32, 21024-21037 DOI: 10.1021/acsnano.4c02056
  • Neutral sphingomyelinase 2 inhibitors based on the pyrazolo[1,5-a]prymidin-3-amine scaffold Katerina Novotna, Ajit G. Thomas, Ondrej Stepanek, Brennan Murphy, Niyada Hin, Jan Skacel, Louis Mueller, Lukas Tenora, Arindom Pal, Jesse Alt, Ying Wu, James Paule, Rana Rais, Barbara S. Slusher, Takashi Tsukamoto European Journal of Organic Chemistry 2023 DOI: 10.1016/j.ejmech.2023.115674.
  • A Far-Red Rotor Fluorogenic Trehalose Probe for Live Mycobacteria Detection and Drug-Susceptibility Testing Nicholas Banahene, Dana M Gepford, Kyle J. Biegas, Daniel H. Swanson, Yen‐Pang Hsu, Brennan A Murphy, Zachary E. Taylor, Irene Lepori, M. Sloan Siegrist, Andrés Obregón‐Henao, Michael S. Van Nieuwenhze, Benjamin M. Swarts Angewandte Chemie 2023 DOI: 10.1002/anie.202213563.
  • High-throughput activity assay for screening inhibitors of the SARS-CoV-2 Mac1 macrodomain Morgan Dasovich, Junlin Zhuo, Jack A. Goodman, Ajit Thomas, Robert Lyle McPherson, Aravinth Kumar Jayabalan, Veronica F. Busa, Shang-Jung Cheng, Brennan A. Murphy, Karli R Redinger, Yousef M. O. Alhammad, Anthony R Fehr, Takashi Tsukamoto, Barbara S. Slusher, Jürgen Bosch, Huijun Wei, Anthony KL Leung ACS Chemical Biology 2021. DOI: 10.1021/acschembio.1c00721.
  • The Pneumococcal Iron Uptake Protein a (PiuA) Specifically Recognizes Tetradentate FeIII bis- and Mono-Catechol Complexes Yifan Zhang, Katherine A. Edmonds, Daniel J. Raines, Brennan A. Murphy, Hongwei Wu, Chuchu Guo, Elizabeth M. Nolan, Michael S. VanNieuwenhze, Anne-K. Duhme-Klair, and David P. Giedroc Journal of Molecular Biology 2020. DOI: 10.1016/j.jmb.2020.08.005.
  • Scalable Synthesis of Orthogonally Protected β-Methyllanthionines by Indium(III)-Mediated Ring Opening of Aziridines Ziran Li, Zachary Gentry, Brennan Murphy, and Michael S. VanNieuwenhze Organic Letters 2019, 21, 2200-2203. DOI: 10.1021/acs.orglett.9b00125.
  • Fluorogenic D-amino acids enable real-time monitoring of peptidoglycan biosynthesis and high-throughput transpeptidation assays Yen-Pang Hsu, Edward Hall, Garrett Booher, Brennan Murphy, Atanas D. Radkov, Jacob Yablonowski, Caitlyn Mulcahey, Laura Alvarez, Felipe Cava, Yves V. Brun, Erkin Kuru, and Michael S. VanNieuwenhze Nature Chemistry 2019, 11, 335-341. DOI: 10.1038/s41557-019-0217-x.
  • Chemoenzymatic Synthesis of Advanced Intermediates for Formal Total Syntheses of Tetrodotoxin Daler Baidilov, Lukas Rycek, John F. Trant, Jordan Froese, Brennan Murphy, and Tomáš Hudlický Angewandte Chemie International Edition 2018, 57, 10994-10998. DOI: 10.1002/anie.201804602.
  • Full color palette of fluorescent D-amino acids for in situ labeling of bacterial cell walls Yen-Pang Hsu, Jonathan Rittichier, Erkin Kuru, Jacob Yablonowski, Erick Pasciak, Srinivas Tekkam, Edward Hall, Brennan Murphy, Timothy K. Lee, Ethan C. Garner, Kerwyn Casey Huang, Yves V. Brun, and Michael S. VanNieuwenhze Chemical Science 2017, 8, 6313-6321. DOI: 10.1039/C7SC01800B.
  • A Formal Approach to Xylosmin and Flacourtosides E and F: Chemoenzymatic Total Synthesis of the Hydroxylated Cyclohexenone Carboxylic Acid Moiety of Xylosmin Mukund Ghavre, Jordan Froese, Brennan Murphy, Razvan Simionescu, and Tomáš Hudlický Organic Letters 2017, 19, 1156-1159. DOI: 10.1021/acs.orglett.7b00194.
  • Rosmarinic Acid, a Rosemary Extract Polyphenol, Increases Skeletal Muscle Cell Glucose Uptake and Activates AMPK Filip Vlavcheski, Madina Naimi, Brennan Murphy, Tomáš Hudlický, and Evangelia Tsiani Molecules 2017, 22, 1669. 10.3390/molecules22101669.
  • Carnosic acid as a component of rosemary extract stimulates skeletal muscle cell glucose uptake via AMPK activation Madina Naimi, Filip Vlavcheski, Brennan Murphy, Tomáš Hudlický, and Evangelia Tsiani Clinical and Experimental Pharmacology and Physiology 2017, 44, 94–102. DOI: 10.1111/1440-1681.12674.
  • Conversion of Thebaine to Oripavine and Other Useful Intermediates for the Semi-synthesis of Opiate-Derived Agents. Synthesis of Hydromorphone Brennan Murphy, Ivan Šnajdr, Aleš Machara, Mary Ann A. Endoma-Arias, Theocharis C. Stamatatos, D. Phillip Cox, and Tomáš Hudlický Advanced Synthesis & Catalysis 2014, 356, 2679-2687. DOI: 10.1002/adsc.201400445.